|
Squamous cell carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the multivariate linear regression model, both rs1051730 and smoking were significant predictors for the size of sq</span>uamous carcinomas.
|
21645942 |
2011 |
|
Smoking Behaviors
|
|
0.700 |
GeneticVariation
|
GWASDB |
Meta-analysis and imputation refines the association of 15q25 with smoking quantity.
|
20418889 |
2010 |
|
Smoking Behaviors
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide meta-analyses of smoking behaviors in African Americans.
|
22832964 |
2012 |
|
Smoking Behaviors
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide meta-analyses identify multiple loci associated with smoking behavior.
|
20418890 |
2010 |
|
Smoking Behaviors
|
|
0.700 |
GeneticVariation
|
GWASDB |
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
|
20418888 |
2010 |
|
Smoking
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.
|
18385739 |
2008 |
|
Smoking
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
|
20418888 |
2010 |
|
Smoking
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analyses identify multiple loci associated with smoking behavior.
|
20418890 |
2010 |
|
Smoking
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Meta-analysis and imputation refines the association of 15q25 with smoking quantity.
|
20418889 |
2010 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Odds ratios per rs1051730 allele for schizophrenia and antipsychotic medication use in ever-smokers in the general population were 1.22 (95% CI: 0.84-1.79) and 1.06 (1.00-1.12).
|
26054357 |
2015 |
|
response to bronchodilator
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
|
Pulmonary Emphysema
|
|
0.010 |
GeneticVariation
|
BEFREE |
Consistently, the rs1051730 A-allele conferred increased risk for emphysema as assessed by CT (P = 0.0097 and P = 0.019), with a pooled OR of 1.39 (CI = 1.15-1.68; P = 0.00051).
|
20007924 |
2010 |
|
psychological distress
|
|
0.010 |
GeneticVariation
|
BEFREE |
In Mendelian randomisation analyses, there was no strong evidence that the minor allele of rs16969968/rs1051730 was associated with depression (OR=1.00, 95% CI 0.95 to 1.05), anxiety (OR=1.02, 95% CI 0.97 to 1.07) or psychological distress (OR=1.02, 95% CI 0.98 to 1.06) in current smokers.
|
25293386 |
2014 |
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We used urinary biomarkers to test whether two linked lung cancer risk variants in CHRNA3 (rs1051730) and CHRNA5 (rs16969968) are associated with intensity of smoking and exposure to a tobacco-specific carcinogenic nitrosamine per cigarette dose.
|
19010884 |
2008 |
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects.
|
18780872 |
2008 |
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We further showed that these two genetic variants on 15q24-25.1 independently influence lung cancer risk (rs1051730: P = 4.42 x 10(-11); OR, 1.60; 95% CI, 1.46-1.74; rs481134: P = 7.01 x 10(-4); OR, 0.81; 95% CI, 0.72-0.92).
|
20395203 |
2010 |
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The CHRNA3 rs1051730 polymorphism has been associated to chronic obstructive pulmonary disease (COPD), lung cancer and nicotine dependence in case-control studies with high smoking exposure; however, its influence on lung function and COPD severity in the general population is largely unknown.
|
22441734 |
2012 |
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Similarly, neither CHRNA3 rs8034191 nor rs1051730 were associated with lung cancer risk.
|
20068085 |
2010 |
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that 2 risk single nucleotide polymorphisms reported in the lung cancer GWA studies-rs8034191: A>G and rs1051730: G>A, located in this 15q24-25.1 region-were not associated with risk of pancreatic cancer.
|
21697764 |
2011 |
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The nicotinic acetylcholine receptor polymorphism (rs1051730) on chromosome 15q25 is associated with major tobacco-related diseases in the general population with additional increased risk of COPD as well as lung cancer.
|
23061658 |
2012 |
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings demonstrated that CHRNA3 gene rs1051730-A allele and AGPHD1 gene rs8034191-T allele might be risk-conferring factors for the development of lung cancer in Caucasians, but not in East-Asians.
|
22701590 |
2012 |
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, the A alleles in CHRNA3 rs1051730 and CHRNA5 rs16969968 were associated with the risk for LC (OR = 1.66, P = 0.07 and OR = 1.57, P = 0.1, respectively) and for COPD (OR = 2.04, P = 0.01 and OR = 1.91, P = 0.02, respectively).
|
29993116 |
2018 |
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We observed a significant association between lung cancer and rs1051730 in pooled population by using allele (OR = 1.30, 95% CI = 1.27-1.34, P < 0.0001), dominant (OR = 1.41, 95% CI = 1.29-1.55, P < 0.0001), recessive (OR = 1.53, 95% CI = 1.42-1.65, P < 0.0001) and additive (OR = 1.75, 95% CI = 1.61-1.90, P < 0.0001) models.
|
26508385 |
2015 |
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The potential association of three polymorphisms in the CHRNA3 (rs1051730(G > A)), CHRNA5 (rs16969968(G > A)), and AGPHD1 (rs8034191(A > G)) with the lung cancer risk has been widely investigated, but the results are inconsistent.
|
27072204 |
2016 |
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The increase in cotinine levels indicated an increased risk of lung cancer with each additional copy of the rs1051730-rs16969968 risk allele (per-allele odds ratio = 1.31, 95% CI = 1.21 to 1.42).
|
22534784 |
2012 |